By Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins (eds.)
Ocular toxicity is sometimes assessed in toxicology experiences performed for regulatory reasons. Ocular anatomy and body structure and the evaluate of ocular toxicity itself may be demanding to scientists considering the protection evaluation of prescription drugs, insecticides and different brokers. Anatomical and physiological adjustments among species can impression the character of ocular results saw following meant or unintentional publicity of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals presents a concise reference addressing ocular anatomy and body structure throughout species that might increase the layout and interpretation of toxicology stories performed for regulatory reasons.
The e-book offers an outline of regimen and complex innovations which are used to evaluate ocular toxicity together with slit lamp biomicroscopy, oblique ophthalmoscopy, electrophysiology and imaging equipment for the anterior and posterior segments of the attention. also, the e-book defines the regulatory expectancies for prescribed drugs meant to regard ocular ailments and for different non-pharmaceutical regulated chemical compounds. With contributions from specialists within the box, Ocular Toxicity in Laboratory Animals is an authoritative, available advisor for toxicologists and different scientists excited by carrying out toxicology stories for regulatory reasons and/or reviewing information from such studies.
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Extra resources for Assessing Ocular Toxicology in Laboratory Animals
Such variables must be considered in construction of study protocols with proper controls established. In general toxicology studies where baseline conditioning is not usually performed, the variables can be limited by the proper use of controls, measuring the intraocular pressures for all animals in all groups at the same time each day and using the same personnel when measuring the pressures. In such studies, evaluating mean intraocular pressure for each group and comparing it both to the initial mean intraocular pressure as well as the control group can further decrease variability between groups.
51. Salminen L. Review: systemic absorption of topically applied ocular drugs in humans. J Ocul Pharmacol Ther. 1990;6(3):243–9. 52. Schulz D, Iliev M, Frueh B, Goldblum D. In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer. Vision Res. 2003;43(6):723–8. 53. Shafiee A, McIntire GL, Sidebotham LC, Ward KW. Experimental determination and allometric prediction of vitreous volume and retina and lens weights in Göttingen minipigs. Vet Ophthalmol.
1990;6(3):243–9. 52. Schulz D, Iliev M, Frueh B, Goldblum D. In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer. Vision Res. 2003;43(6):723–8. 53. Shafiee A, McIntire GL, Sidebotham LC, Ward KW. Experimental determination and allometric prediction of vitreous volume and retina and lens weights in Göttingen minipigs. Vet Ophthalmol. 2008;11:193–6. 54. Shiratani T, Shimizu K, Fujisawa K, Uga S, Nagano K, Murakami Y. Crystalline lens changes in porcine eyes with implanted phakic IOL (ICL) with a central hole.
Assessing Ocular Toxicology in Laboratory Animals by Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins (eds.)