By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)
The volumes integrated in Antimicrobial Drug Resistance symbolize the 1st entire, multidisciplinary reference masking the world of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from simple technology, medical, and epidemiological perspectives.
The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and powerful avenues for drug improvement. With the emergence of extra drug-resistant lines, the method of facing the drug resistance challenge needs to comprise the examine of alternative elements of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to study using new genomic details. those ways will allow the layout of novel suggestions to advance new antibiotics and defend the effectiveness of presently on hand ones.
The moment quantity, Antimicrobial Drug Resistance, medical and Epidemiological Aspects, is dedicated to the medical points of drug resistance. even if there's facts that constrained use of a particular antibiotic will be through a lessen in drug resistance to that agent, drug resistance regulate isn't really simply accomplished. therefore, the infectious disorder health care provider calls for enter from the medical microbiologist and an infection keep an eye on professional to make knowledgeable offerings for the potent remedy of assorted traces of drug-resistant pathogens in person patients.
This 2-volume set is a crucial reference for college students in microbiology, infectious affliction physicians, scientific scholars, uncomplicated scientists, drug improvement researchers, microbiologists, epidemiologists, and public wellbeing and fitness practitioners.
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Additional info for Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects
162. encoding dihydropteroate synthase and characterization of the enzyme. J Bacteriol 1987;169:4320–4326 Maskell JP, Sefton AM, Hall LM. Mechanism of sulfonamide resistance in clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother 1997;41:2121–2126 Padayachee T, Klugman KP. Novel expansions of the gene encoding dihydropteroate synthase in trimethoprim–sulfamethoxazoleresistant Streptococcus pneumoniae. Antimicrob Agents Chemother 1999;43:2225–2230 Moore HF, Chesney AM. A study of ethylhydrocuprein (optochin) in the treatment of acute lobar pneumonia.
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This can be achieved by amino acid substitutions in the transpeptidase domain of the PBPs (19, 22). One point mutation can result in slight increase in the penicillin MIC. Normally more than one mutation is needed for intermediate-level beta-lactam resistance. Highly resistant strains have accumulated several mutations in the PBPs. Based on the data obtained from S. pneumoniae; these highly resistant strains may also need mutations other than PBP (19). Accumulation of several mutations in the PBPs may also lead to lethal mutations.
Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects by Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)