By Oscar; Latner, A. L. Bodansky
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The target of this publication is to make its readers higher proficient and extra severe shoppers of scientific examine to aid them realize the strengths and the weaknesses of clinical guides. In doing so, the reader should be in a position to distinguish patient-important and methodologically sound experiences from these having obstacles in layout, behavior and interpretation.
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Extra resources for Advances in Clinical Chemistry, Vol. 19
Linearity is considered acceptable if (A1 - A ? ) - ( A , - i13) x 100 ( A , - A3) lies between -5 and +5. If these limits are exceeded, the result is printed with a message indicating an accelerating (“ACC”)or decreasing (“DEC) rate. As has already been mentioned, no results printed without error messages were found to be accompanied by unacceptable traces when the performance of the analyzer was monitored by a chart recorder in this laboratory, and the incidence of results with error messages but with acceptable chart traces was very small.
If these limits are exceeded, the result is printed with a message indicating an accelerating (“ACC”)or decreasing (“DEC) rate. As has already been mentioned, no results printed without error messages were found to be accompanied by unacceptable traces when the performance of the analyzer was monitored by a chart recorder in this laboratory, and the incidence of results with error messages but with acceptable chart traces was very small. Good correlation was found between results given by the 3500 analyzer and those by other methods for assays of aspartate transaminase, creatine kinase, and lactate dehydrogenase in serum (Fig.
Several automatic enzyme analyzers retain the conventional strip-chart recorder, or allow such a recorder to be fitted, on which the analog signal is displayed, in addition to incorporating calculation programs. If the operator is prepared to monitor each successive trace, the calculated re- AUTOlMATIC ENZYMX ANALYZERS 23 sult can be based simply on two readings separated by a fixed-time interval, assessment of linearity being entirely the operator’s responsibility. This simplified approach loses some of the benefits of automation, however, and where an assessment of linearity based on at least 3 points on the progress curve is made by the instrument itself, the operator need only scrutinize the chart record in the case of those samples for which the criteria of linearity set by the calculation program have not been met.
Advances in Clinical Chemistry, Vol. 19 by Oscar; Latner, A. L. Bodansky