By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)
The manuscripts during this quantity have been contributed via the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly was once prepared to commemorate the outline of acromegaly by means of the French general practitioner Pierre Marie, in 1886. The contributors of the clinical Committee spent many hours helping us in making sure a superb assembly. The help of Serono Symposia, united states in all levels of the making plans and execution of the assembly was once basically preferred and was once hugely expert. precise acceptance roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in scientific heritage led him to commit loads of time and private rate in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the existence and instances of Marie used to be a unprecedented evaluate of the cultural, social, and medical backgrounds during which Marie got here to explain the affliction, acromegaly. Dr. Guillemin' s findings, that have been offered on the major ceremonial dinner in a most suitable audiovisual presentation, have been sincerely the spotlight of the assembly and should lengthy be remembered by way of the attendees. We have been additionally commemorated through the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her deal with on the ceremonial dinner, Dr. Granier supplied a number of pleasant and intimate vignettes pertaining to Pierre Marie, utilizing outdated family members documents and pictures. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the historic surroundings of the meeting.
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The manuscripts during this quantity have been contributed by means of the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be prepared to commemorate the outline of acromegaly via the French health care provider Pierre Marie, in 1886. The participants of the clinical Committee spent many hours supporting us in making sure a superb assembly.
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Extra resources for Acromegaly: A Century of Scientific and Clinical Progress
These pituitary cultures, derived from a variety of normal and diseased pituitaries, including acromegaly, showed a predominant secretory product, GH 22K , with evidence for GH 20K ('" 5%) and (possibly) an acidic form ( < 5%), in addition to big forms ~T7). No evidence of cleaved forms in detectable amounts was obtained, either extracellularly or intracellularly. This was in marked contradistinction to pituitary extracts, where variable amounts of cleaved forms are universally found (7,8,17), presumably as a result of proteolysis during extraction and storage (19).
Although it is generally agreed that the desamido form is produced by alkali, it is not certain whether the acidic form seen in extracts of fresh pituitary glands (20) is a deamidated form of the peptide. Liberti et a1. (21) demonstrated phosphorylated ovine GH in their preparations of the hormone and Oetting et a1. (22) showed that prolactin is readily phosphorylated in the rat pituitary gland. Using isoelectric focusing, at least 6 acidic components have been seen in purified preparations of GH.
Such assays will be extremely useful in the measurement of the various peptides in numerous metabolic disorders. To date, this approach has been hindered by lack of discriminating antisera (production of such antisera has not been possible by direct i1lllllunization). In the meantime, i1lllllUnob10tting techniques can be used to give preliminary analyses of sera as demonstrated by Markoff et a1. (28) and Sinha et a1. (29) for the GH 20K while Baumann et a1. (30) were the first to detect GH 20K in serum by a combined electrophoresis-RIA techniques.
Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)