Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins's Acromegaly: A Century of Scientific and Clinical Progress PDF

By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

ISBN-10: 1461290643

ISBN-13: 9781461290643

ISBN-10: 1461319137

ISBN-13: 9781461319139

The manuscripts during this quantity have been contributed via the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly was once prepared to commemorate the outline of acromegaly by means of the French general practitioner Pierre Marie, in 1886. The contributors of the clinical Committee spent many hours helping us in making sure a superb assembly. The help of Serono Symposia, united states in all levels of the making plans and execution of the assembly was once basically preferred and was once hugely expert. precise acceptance roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in scientific heritage led him to commit loads of time and private rate in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the existence and instances of Marie used to be a unprecedented evaluate of the cultural, social, and medical backgrounds during which Marie got here to explain the affliction, acromegaly. Dr. Guillemin' s findings, that have been offered on the major ceremonial dinner in a most suitable audiovisual presentation, have been sincerely the spotlight of the assembly and should lengthy be remembered by way of the attendees. We have been additionally commemorated through the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her deal with on the ceremonial dinner, Dr. Granier supplied a number of pleasant and intimate vignettes pertaining to Pierre Marie, utilizing outdated family members documents and pictures. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the historic surroundings of the meeting.

Show description

Read or Download Acromegaly: A Century of Scientific and Clinical Progress PDF

Best clinical books

evaluating clinical research: All that glitters is not gold - download pdf or read online

The target of this booklet is to make its readers higher proficient and extra serious shoppers of medical study to aid them realize the strengths and the weaknesses of medical courses. In doing so, the reader might be capable of distinguish patient-important and methodologically sound stories from these having barriers in layout, behavior and interpretation.

Get Clinical Pathology of Pancreatic Disorders PDF

In scientific Pathology of Pancreatic issues, prime scientific gurus comprehensively survey a few of the sorts of pancreatic issues amenable to medical laboratory assessments and evaluation intimately how those exams are used for the prognosis, diagnosis, and administration of sufferers. The illnesses lined extensive diversity from endocrine, neoplastic, and exocrine problems to inflammatory and protracted problems, and comprise diabetes, the digestive disturbances linked to pancreatic insufficiency, and present developments in pancreas transplantation.

Read e-book online Acromegaly: A Century of Scientific and Clinical Progress PDF

The manuscripts during this quantity have been contributed by means of the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be prepared to commemorate the outline of acromegaly via the French health care provider Pierre Marie, in 1886. The participants of the clinical Committee spent many hours supporting us in making sure a superb assembly.

Extra resources for Acromegaly: A Century of Scientific and Clinical Progress

Example text

These pituitary cultures, derived from a variety of normal and diseased pituitaries, including acromegaly, showed a predominant secretory product, GH 22K , with evidence for GH 20K ('" 5%) and (possibly) an acidic form ( < 5%), in addition to big forms ~T7). No evidence of cleaved forms in detectable amounts was obtained, either extracellularly or intracellularly. This was in marked contradistinction to pituitary extracts, where variable amounts of cleaved forms are universally found (7,8,17), presumably as a result of proteolysis during extraction and storage (19).

Although it is generally agreed that the desamido form is produced by alkali, it is not certain whether the acidic form seen in extracts of fresh pituitary glands (20) is a deamidated form of the peptide. Liberti et a1. (21) demonstrated phosphorylated ovine GH in their preparations of the hormone and Oetting et a1. (22) showed that prolactin is readily phosphorylated in the rat pituitary gland. Using isoelectric focusing, at least 6 acidic components have been seen in purified preparations of GH.

Such assays will be extremely useful in the measurement of the various peptides in numerous metabolic disorders. To date, this approach has been hindered by lack of discriminating antisera (production of such antisera has not been possible by direct i1lllllunization). In the meantime, i1lllllUnob10tting techniques can be used to give preliminary analyses of sera as demonstrated by Markoff et a1. (28) and Sinha et a1. (29) for the GH 20K while Baumann et a1. (30) were the first to detect GH 20K in serum by a combined electrophoresis-RIA techniques.

Download PDF sample

Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)


by Steven
4.2

Rated 4.49 of 5 – based on 7 votes